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Friday, July 31, 2020 | History

2 edition of An experimental investigation of the toxicity of certain organic arsenic components found in the catalog.

An experimental investigation of the toxicity of certain organic arsenic components

George Byron Roth

An experimental investigation of the toxicity of certain organic arsenic components

by George Byron Roth

  • 233 Want to read
  • 25 Currently reading

Published by Govt. print. off. in Washington .
Written in English

    Subjects:
  • Salvarsan,
  • Arsenic compounds -- Toxicology

  • Edition Notes

    Other titlesExperimental investigation of the toxicity of certain organic arsenic components.
    Statementby George B. Roth. II. On the toxicity of emetine hydrochloride, with special reference to the comparative toxicity of various market preparations ; by Gleason C. Lake.
    SeriesBulletin / Hygienic Laboratory -- no.113, Bulletin (Hygienic Laboratory (U.S.)) -- no.113.
    ContributionsHygienic Laboratory (U.S.)
    The Physical Object
    Pagination61p. :
    Number of Pages61
    ID Numbers
    Open LibraryOL19935136M

    Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. Long-term exposure can result in thickening of the skin, darker skin, abdominal pain, diarrhea, heart disease, numbness, and cancer. lize arsenic, such as rice, presents multiple pathways for human exposure. Table 1 lists potential environmental or nonoccupa-tional exposures to arsenic. Dietary exposure to organic arsenic is of less concern than iAs exposure. Fish, seafood, seaweed, and aquatic sediment may contain organic arsenic, commonly in the form of arsenobetaine and.

      Arsenic is an element and is a naturally occurring mineral found widely in the environment. Arsenic exists in four common valence states. Arsenic is widely used commercially, a fact that increases the risk of overexposure. Workers may be overexposed occupationally to arsenic. Inorganic arsenic is generally more toxic than organic arsenic. arsenic compounds are similar and depend on the dose and bioavailability of the substance. The trivalent arsenic compounds are three to four times more toxic than the corresponding pentavalent compounds. The oral LD 50 values for inorganic arsenic compounds, depending on the arsenic species and the experimental animal, are in the.

    Arsenic toxicity is a global health problem affecting many millions of people. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Arsenic is present as a contaminant in many traditional remedies. Arsenic trioxide is now used to treat acute promyelocytic leukaemia. Science Report – A review of the toxicity of arsenic in air Background Arsenic is a metalloid with a complex chemistry, which can form a number of inorganic and organic compounds. Inorganic arsenic occurs in many minerals and is widely found in rocks, soils and sediments. It can exist in several oxidation states, the most common being the.


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An experimental investigation of the toxicity of certain organic arsenic components by George Byron Roth Download PDF EPUB FB2

Arsenic-containing seafood is the main route of arsenic access to the human body. Arsenobetaine, the major organic form of arsenic in seafood, is non-toxic and/or non-carcinogenic to humans.

The majority of organoarsenicals present in the seafood are rapidly. About this book This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives.

• Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health.

The book takes readings systematically through the target organs, before detailing current preventative and counter measures.

Arsenic poisoning is a global health issue affecting millions of people worldwide through environmental and occupational exposure, as well as intentional suicide and homicide attempts. Although arsenic homicides commonly receive media publicity, the primary source of arsenic toxicity to the general population is by contaminated water, soil and food by: 4.

A lot of arsenic compounds are toxic and cause acute and chronic poisoning. In aqueous environment the inorganic arsenic species arsenite (As(III)) and arsenate (As(V)) are the most abundant species. The mobility of these species is influenced by the pH value, the redox potential, and the presence of adsorbents such as oxides and hydroxides of Cited by: Environmental occurrence.

Arsenic is the 20 th most common element in the earth’s crust, and is emitted to the environment as a result of volcanic activity and industrial activities. Mining, smelting of non-ferrous metals and burning of fossil fuels are the major anthropogenic sources of arsenic contamination of air, water, and soil (primarily in the form of arsenic trioxide).

Except for the organic arsenic acids, Factors affecting toxicity of arsenic. In the environment, the degree of toxicity of As is on the enzyme activities of certain fish have been studied. main sources of dietary intake.

However, the arsenic content of fish and shellfish usually involves organic compounds (e.g. arsenobetaine) that are of low toxicity. In areas where arsenic is naturally present at high levels, food (e.g. rice) prepared with high-arsenic water.

Dominic B. Fee, in Clinical Neurotoxicology, DIAGNOSTIC TESTING. Arsenic toxicity is confirmed by demonstrating elevated concentrations of arsenic in the body. Assessing urine is the mainstay, with hour collections better than spot urine testing; hour urine levels greater than 50 to μg or spot urine levels greater than 35 to 50 μg/L are consistent with acute arsenic toxicity.

Although reduced from in the past, arsenic, primarily in organic forms, is also used in a range of agricultural products.

Arsine is used in the microelectronics industry and in semiconductor manufacture. (1) Until the s, inorganic arsenic was used as therapeutic agents in. The results suggest that CHS is very effective in binding arsenic even at mg C/l concentrations which appears to be sufficient to reduce the Microtox ® toxicity of even the very toxic 5 mg/l arsenic concentration.

A comparison of organic and inorganic pesticide toxicity reduction. Studies of arsenic in drinking water suggest that arsenic can cause skin, lung, liver, kidney, and bladder cancer in 1 in cases.

The fatal dose is to mg of arsenious oxide and the fatal period is usually 2 to 3 days. The toxicity rating is 5 for all arsenic salts, except arsenic trioxide. Environmental contamination with arsenic (As) is a global environmental, agricultural and health issue due to the highly toxic and carcinogenic nature of As.

Exposure of plants to As, even at very low concentration, can cause many morphological, physiological, and biochemical changes.

The recent research on As in the soil-plant system indicates that As toxicity to plants varies with its. Background: Chronic arsenic exposure is a worldwide health problem. How arsenic exposure promotes a variety of diseases is poorly understood, and specific relationships between experimental and human exposures are not established.

We propose phenotypic anchoring as a means to unify experimental observations and disease outcomes. Arsenic is a naturally occurring element widely distributed in the earth's crust.

In the environment, arsenic is combined with oxygen, chlorine, and sulfur to form inorganic arsenic compounds. Arsenic in animals and plants combines with carbon and hydrogen to form organic arsenic compounds.

Inorganic arsenic compounds are mainly used to preserve wood. The primary method of metabolizing arsenic in humans is methylation. Although once considered the main mechanism of detoxification, studies have implied the existence of other more important arsenic detoxification mechanisms in mammals.

The main route of arsenic excretion is in the urine. Humans excrete a combination of inorganic arsenic and its mono and dimethylated metabolites in the urine. General population exposure to arsenic is mainly via intake of food and drinking water.

Food is the most important source, but in some areas, arsenic in drinking water is a significant source of exposure to inorganic c contamination in groundwater has become an additional concern vis-à-vis its use for irrigation purposes and its subsequent entry into the food-chain through.

The organic arsenic in food and. Inherent toxicity associated to chemical components in CCA. Evaluation of certain food addi tives contaminants. Sixty-first report of the. 1. Introduction. Contamination of air, soil, and water resources with potentially toxic elements (PTEs) is a global environmental issue [1,2].Most of the PTEs are toxic to plants and animals including humans [3,4,5].Among the PTEs, arsenic (As) is considered as one of the most highly toxic and carcinogenic [6,7,8,9].The US Environmental Protection Agency (EPA) and the International.

The main symptom of arsenic toxicity is fatigue. Arsenic is a very potent mitochondrial poison. This metal poisons the enzymes that transport nutrients into mitochondria – the cell’s energy producers. Without nutrients, the mitochondria do not produce the energy you need and fatigue results.

Specific arsenic toxic symptoms include. Liver and kidneys of healthy animals rarely contain > ppm arsenic (wet wt); toxicity is associated with tissue concentrations >3 ppm (wet wt). The determination of arsenic in stomach contents is of value usually within the first 24–48 hr after ingestion.

The concentration of arsenic in urine can be high for several days after ingestion. Evaluation for arsenic toxicity requires a detailed history, including environmental and occupational exposure history, physical examination, and laboratory testing. For recent and chronic exposure, the hour urine collection for arsenic is the most useful laboratory test.

Organic arsenic from recent seafood ingestion (last 48 hours) may produce a positive urine test for total arsenic.Arsenic is commonly found in many foods both in its apparently nontoxic organic form and also in the more toxic inorganic form.

Such arsenic has been reported in milk and dairy products, beef, pork, poultry, and cereal. Arsenic is also often found in rice, representing a potentially serious source of exposure in certain at-risk populations.